A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the risk of congenital malformations.

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Persistent URL dx.doi.org/10.1038/s41574-018-0012-6, hdl.handle.net/1765/105933
Journal Nature Reviews Endocrinology
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Korevaar, T.I.M, & Peeters, R.P. (2018). Antithyroid drugs and congenital malformations. Nature Reviews Endocrinology, 1–2. doi:10.1038/s41574-018-0012-6