Antithyroid drugs and congenital malformations
A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the risk of congenital malformations.
|Persistent URL||dx.doi.org/10.1038/s41574-018-0012-6, hdl.handle.net/1765/105933|
|Journal||Nature Reviews Endocrinology|
Korevaar, T.I.M, & Peeters, R.P. (2018). Antithyroid drugs and congenital malformations. Nature Reviews Endocrinology, 1–2. doi:10.1038/s41574-018-0012-6