Invasive aspergillosis is the most common invasive fungal disease in patients with acute myeloid leukemia and recipients of allogeneic hematopoietic stem cell transplantation. Not only does it lead to a considerable morbidity and mortality, but also to an increase in medical costs. Triazole resistance in A. fumigatus has emerged over the past decade and is posing a worrisome challenge for diagnostics and treatment. Given these facts, it is essential to optimize the management of invasive aspergillosis in this patient group. This thesis focusses on invasive aspergillosis in high-risk patients with an underlying hematological disease and in particular on its epidemiology, prevention and diagnostics.

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A. Verbon (Annelies) , J.J. Cornelissen (Jan) , B.J.A. Rijnders (Bart)
Erasmus University Rotterdam
Department of Medical Microbiology and Infectious Diseases

Chong, G.-L. (2018, June 5). Invasive Aspergillosis in Clinical Hematology : diagnosis and impact on triazole resistance. Retrieved from

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