Targeting Wnt/β-catenin Signaling in Liver Cancers
Therapie gericht op Wnt/β-catenine signalering in leverkankers
As one of the critical contributing factors to hepatocellular carcinoma (HCC) growth, aberrant activation of Wnt/β-catenin signaling derives from a variety of molecular alterations involved in this pathway, especially mutations of β-catenin and AXIN1. Although a variety of drugs targeting Wnt/β-catenin signaling have been developed, most of them have not been thoroughly tested for liver cancer. In the current thesis, I first explored the effectiveness of two classes of drugs in a panel of HCC cell lines, i.e. an extracellular Wnt secretion inhibitor and cytosolic tankyrase inhibitor. Next, we compared the response and sensitivity for these inhibitors depending on the specific β-catenin signaling defect present in these HCC cell lines, i.e. CTNNB1 or AXIN1 mutations and achieved a better understanding of the mechanism through which AXIN1 mutations contribute to HCC cell growth. Lastly, we found STRAP as a new potential molecular target regulating Wnt/β-catenin signaling in HCC.
|Keywords||Wnt/β-catenin Signaling, liver cancer, hepatocellular carcinoma|
|Promotor||M.P. Peppelenbosch (Maikel) , M.J.M. Smits (Ron)|
|Publisher||Erasmus University Rotterdam|
Wang, W. (2018, June 27). Targeting Wnt/β-catenin Signaling in Liver Cancers. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/105989