Connecting B cell differentiation pathways and antibody deficiencies
B cel differentiatie routes en antistofdeficiënties verbonden
The studies described in this thesis help understand why disturbances in specific genes and processes lead to antibody deficiencies. They showed that B cell precursor development in bone marrow is not a simple linear process, but rather a complex interplay of processes that make every individual cell follow its own route of maturation into a naive B cell. Furthermore, these studies showed that subtle differences in protein function can explain phenotypical differences between different disease entities in CD19- complex deficiencies. Showing how genotype-phenotype correlations can be a tool in patient-prognostics. These studies also showed that the balance in the PI3K/PTEN-AKT signaling cascade is critically important for both humoral and anti-viral immunity, since disturbances lead to antibody deficiencies and reduced viral immunity due to exhaustion. This is especially important in the context of new, personalized, specific treatments for these patients.
|Keywords||primary antibody deficiencies, B cells, B cell differentiation, bone marrow|
|Promotor||J.J.M. van Dongen (Jacques) , M. van der Burg (Mirjam)|
|Publisher||Erasmus University Rotterdam|
|Note||For copyright reasons there is a (partial) embargo for this dissertation|
Wentink, M.W.J. (2018, July 4). Connecting B cell differentiation pathways and antibody deficiencies. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/105999