The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become clear that the functions of the UPR stretch far beyond their canonical role and intersect with seemingly unrelated functions such as innate immunity and antigen presentation. The aim of the present review is to dissect how the UPR interferes directly and indirectly with the major processes of MHC-I and MHC-II antigen presentation.

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Persistent URL dx.doi.org/10.1016/j.coi.2018.04.020, hdl.handle.net/1765/106377
Journal Current Opinion in Immunology
Citation
Osorio, F, Lambrecht, B.N.M, & Janssens, S. (2018). Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways. Current Opinion in Immunology (Vol. 52, pp. 100–107). doi:10.1016/j.coi.2018.04.020