Tailoring treatment strategies for colorectal liver metastasis

This thesis describes studies aimed at optimizing and thus tailor treatment strategies for the individual patient with colorectal liver metastases. Aims were to:
- Conduct a multicenter randomized controlled trial to assess the effect of neo-adjuvant chemotherapy in high-risk resectable patients;
- Evaluate and improve logistics of multicenter randomized trials in the Netherlands in general;
- Identify and evaluate new biomarkers in order to improve patient selection for various treatment modalities (prognostic/predictive markers);
- Optimize patient referral for surgery and assessment of resectability for patients with CRLM;
- Assess and improve the value of surveillance after curative treatment for colorectal cancer