Catheter design optimization for practical intravascular photoacoustic imaging (IVPA) of vulnerable plaques
Intravascular photoacoustic/ultrasound imaging (IVPA/US) can image the structure and composition of atherosclerotic lesions identifying lipid-rich plaques ex vivo and in vivo. In the literature, multiple IVPA/US catheter designs were presented and validated both in ex-vivo models and preclinical in-vivo situations. Since the catheter is a critical component of the imaging system, we discuss here a catheter design oriented to imaging plaque in a realistic and translatable setting. We present a catheter optimized for light delivery, manageable flush parameters and robustness with reduced mechanical damage risks at the laser/catheter joint interface. We also show capability of imaging within sheath and in water medium.
|Intravascular Photoacoustics, IVPA catheter, IVPA sheath, lipid-rich plaque imaging|
|Diagnostic and Therapeutic Applications of Light in Cardiology 2018|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Iskander-Rizk, S, Wu, M, Springeling, T, Mastik, F, Beurskens, R, van der Steen, A.F.W, & van Soest, G. (2018). Catheter design optimization for practical intravascular photoacoustic imaging (IVPA) of vulnerable plaques. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. doi:10.1117/12.2287364