A new model for the pressure relaxation of the left ventricle is proposed. The model presumes that the myocardium relaxes asynchronously, but that when regions begin to relax, after a delay, the local wall stress decays as a mono-exponential process. This formulation results in an apparently bi-exponential process (two time constants) which has been previously reported. It is shown that the ratio of the two time constants (T2/T1) can be interpreted as the fraction of the myocardium which relaxes synchronously. Data are presented illustrating the model during transient coronary occlusion in patients undergoing percutaneous transluminal coronary angioplasty.

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doi.org/10.1093/cvr/17.8.482, hdl.handle.net/1765/107188
Cardiovascular Research
Department of Cardiology

Brower, R., Meij, S., & Serruys, P. (1983). A model of asynchronous left ventricular relaxation predicting the bi-exponential pressure decay. Cardiovascular Research (Vol. 17, pp. 482–488). doi:10.1093/cvr/17.8.482