Background: There is no published evidence on pregnancy after right ventricular outflow tract (RVOT) reconstruction with an allograft. Objectives: The aim of this study was to describe pregnancy outcomes in women with allografts in the RVOT position. Methods: A retrospective cohort study of consecutive female patients who received allografts in the RVOT position was conducted. All patients between 18 and 50 years of age were screened for cardiac, obstetric, and fetal outcomes of completed (≥20 weeks’ gestation) pregnancies. Results: In total, 196 women met the inclusion criteria, of whom 56 had 89 completed pregnancies. Information could be retrieved in 84 cases (94.4%). Mean maternal age was 29.6 ± 4.3 years, with 80 patients (95.2%) in New York Heart Association functional class I or II. The most common diagnosis was tetralogy of Fallot. All women survived pregnancy. There were 2 cases (2.4%) of heart failure (arrhythmic and diastolic dysfunction), 1 case (1.2%) of infection (chorioamnionitis), and 3 cases (3.6%) of pre-eclampsia. No other cardiac or obstetric events were reported. All children were born alive at a median gestational age of 38.4 weeks (interquartile range: 36.9 to 39.6 weeks), with a median birthweight of 2,930 g (interquartile range: 2,535 to 3,385 g). Seventeen (20.2%) were small for gestational age, and 20 (23.8%) were premature. Neonatal death was reported in 2 children (2.5%). Preconception pulmonary regurgitation was associated with an increased probability of pre-term labor (odds ratio: 2.610; 95% confidence interval: 1.318 to 5.172). Compared with the general Dutch population, pre-term delivery (25.0% vs. 7.4%, p < 0.001) and children small for gestational age (20.2% vs. 10.0%, p = 0.002) were more common. Conclusions: Women in good cardiac health after RVOT reconstruction with allografts can safely experience pregnancy and labor. The higher incidence of pre-term delivery and children small for gestational age warrants special attention.

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Keywords allograft, congenital heart disease, pregnancy
Persistent URL dx.doi.org/10.1016/j.jacc.2018.03.522, hdl.handle.net/1765/107230
Journal Journal of the American College of Cardiology
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Citation
Romeo, J.L.R. (Jamie L.R.), Takkenberg, J.J.M, Roos-Hesselink, J.W, Hanif, M. (Milad), Cornette, J.M.J. (Jerome M.J.), van Leeuwen, W.J, … Mokhles, M.M. (2018). Outcomes of Pregnancy After Right Ventricular Outflow Tract Reconstruction With an Allograft Conduit. Journal of the American College of Cardiology, 71(23), 2656–2665. doi:10.1016/j.jacc.2018.03.522