In 2016, the third version of guidelines for the diagnosis and treatment of neuroendocrine tumors (NETs) has been published by the European Neuroendocrine Tumor Society (ENETS). These guidelines reflect the progress in treatment of NETs, and by comparing the newest guidelines with the first guidelines of 2001, this progress can be clearly recognized. Diagnostic accuracy has been increased by the introduction of PET-CT with Ga-labelled somatostatin analogs, and multiple new treatments and treatment schedules have been developed, like peptide receptor radiotherapy with radiolabeled somatostatin analogs, or targeted therapies. Evidence and indications for these therapies are discussed in the ENETS guidelines. In this review, we aim to show the progress in NET diagnosis and treatment on the basis of the advances in the guidelines, but also to discuss the unsolved questions and unmet needs which still remain.

Additional Metadata
Keywords ENETS Guidelines, First-/second-line treatment, Neuroendocrine tumor
Persistent URL dx.doi.org/10.1159/000486096, hdl.handle.net/1765/107438
Journal Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships
Citation
Zandee, W.T, & de Herder, W.W. (2018). The Evolution of Neuroendocrine Tumor Treatment Reflected by ENETS Guidelines. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 106(4), 357–365. doi:10.1159/000486096