The widely used chemotherapeutic cisplatin causes ototoxicity as late-term side effect. In this issue, Benkafadar et al () decipher the mechanism of cisplatin-induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ototoxicity without influencing chemotherapeutic efficacy. These findings may open exciting perspectives for reducing (late-term) side effects of cancer treatment.

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Journal EMBO Molecular Medicine
Nonnekens, J, & Hoeijmakers, J.H.J. (2016). After surviving cancer, what about late life effects of the cure?. EMBO Molecular Medicine. doi:10.15252/emmm.201607062