2017-02-15
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
Publication
Publication
Nature Immunology , Volume 18 - Issue 3 p. 313- 320
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3 -/- mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.
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| doi.org/10.1038/ni.3657, hdl.handle.net/1765/108056 | |
| Nature Immunology | |
| Organisation | Department of Pulmonology |
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Hammad, H., Vanderkerken, M. (Matthias), Pouliot, P., Deswarte, K., Toussaint, W., Vergote, K., Vandersarren, L. (Lana), Janssens, S., Ramou, I. (Ioanna), Savvides, S.N. (Savvas N.), Haigh, K., Hendriks, R., Kopf, M. (Manfred), Craessaerts, K. (Katleen), de Strooper, B., Kearney, J.F. (John F.), Conrad, D.H. (Daniel H.)& Lambrecht, B. (2017). Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Nature Immunology, 18(3), 313–320.https://doi.org/10.1038/ni.3657 |
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