Factors determining human-to-human transmissibility of zoonotic pathogens via contact
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission. The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens.
|Persistent URL||dx.doi.org/10.1016/j.coviro.2016.11.004, hdl.handle.net/1765/108125|
|Journal||Current Opinion in Virology|
Richard, M, Knauf, S. (Sascha), Lawrence, P. (Philip), Mather, A.E. (Alison E), Munstert, V, Müller, M.A, … Kuiken, T. (2017). Factors determining human-to-human transmissibility of zoonotic pathogens via contact. Current Opinion in Virology (Vol. 22, pp. 7–12). doi:10.1016/j.coviro.2016.11.004