Response by Mulder et al to Letter Regarding Article, "baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)"

In Response:
We thank Freeman for his response to our article Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands).1 We indeed assessed the effect of mean arterial pressure (MAP) on functional outcome in our analysis, which is shown in Figure IVB in the online-only Data Supplement (the supplements were updated because this figure was incorrectly showing Figure 1 of the article). The effect was U shaped; both low and high MAP were associated with poor functional outcome, comparable to systolic blood pressure (SBP). In our article, we focused on SBP because it showed to have a stronger correlation with functional outcome than MAP and diastolic blood pressure. [...]