Metastatic involvement of the pancreas occurs in 5% of patients affected by advanced malignancies. Surgical resection has been reported by number of authors as a valuable option to improve disease control, in particular in patients with limited disease burden and favourable histotypes; however, the benefit of this procedure has been questioned due to patient selection, technical challenges and relevant risk of perioperative mortality and severe complications. In the present study, a cohort of surgically unfit patients affected by a solitary metastasis in the pancreas from various primary tumours received stereotactic radiotherapy with an ablative dose schedule, obtaining promising local and distant disease progression-free delay with minor toxicity. This is the first report to our knowledge on the use of ablative stereotactic radiotherapy of metastasis in the pancreatic gland.

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Loi, M., Magallon-Baro, A. (A.), Papalazarou, C. (C.), Milder, M. (M.), & Nuyttens, J. (2017). Robotic stereotactic treatment for malignant metastasis of solid tumour in the pancreas: A multiple case report and review of literature Radiothérapie en conditions stéréotaxiques de métastases intrapancréatiques: cas cliniques et revue de la littérature. Cancer/Radiotherapie, 21(8), 784–787. doi:10.1016/j.canrad.2017.06.012