Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials
Neuro-Oncology , Volume 19 - Issue 1 p. 12- 21
Patients with low-grade glioma frequently have brain tumor-related epilepsy, which is more common than in patients with high-grade glioma. Treatment for tumor-associated epilepsy usually comprises a combination of surgery, anti-epileptic drugs (AEDs), chemotherapy, and radiotherapy. Response to tumor-directed treatment is measured primarily by overall survival and progression-free survival. However, seizure frequency has been observed to respond to tumor-directed treatment with chemotherapy or radiotherapy. A review of the current literature regarding seizure assessment for low-grade glioma patients reveals a heterogeneous manner in which seizure response has been reported. There is a need for a systematic approach to seizure assessment and its influence on health-related quality-of-life outcomes in patients enrolled in low-grade glioma therapeutic trials. In view of the need to have an adjunctive metric of tumor response in these patients, a method of seizure assessment as a metric in brain tumor treatment trials is proposed.
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Avila, E.K. (Edward K.), Chamberlain, M.C, Schiff, D, Reijneveld, J.C, Armstrong, T.S, Rudà, R, … DeAngelis, L.M. (Lisa M.). (2017). Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials. Neuro-Oncology (Vol. 19, pp. 12–21). doi:10.1093/neuonc/now190