Circulating Tumor Cells in a Phase 3 Study of Docetaxel and Prednisone with or without Lenalidomide in Metastatic Castration-resistant Prostate Cancer
Elevated circulating tumor cell (CTC) blood levels (≥5 cells/7.5 ml) convey a negative prognosis in metastatic castration-resistant prostate cancer but their prognostic significance in patients receiving chemotherapy is uncertain. The association between CTC counts (at baseline or after treatment), overall survival (OS), and response to docetaxel with lenalidomide was evaluated in a 208-patient subset from the MAINSAIL trial, which compared docetaxel-prednisone-lenalidomide and docetaxel-prednisone-placebo in metastatic castration-resistant prostate cancer patients. Baseline CTCs were < 5 cells/7.5 ml blood in 87 (42%) patients and ≥5 cells/7.5 ml in 121 (58%) patients. Neither tumor response nor prostate-specific antigen response correlated with baseline CTCs. However, CTC count ≥5 cells/7.5 ml was significantly associated with lower OS (hazard ratio: 3.23, p = 0.0028). Increases in CTCs from <5 cells/7.5 ml to ≥5 cells/7.5 ml after three cycles were associated with significantly shorter OS (hazard ratio: 5.24, p = 0.025), whereas CTC reductions from ≥5 cells/7.5 ml to <5 cells/7.5 ml were associated with the best prognosis (p = 0.003). Patient summary Our study in metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy, with or without lenalidomide, showed that patient survival was best predicted by circulating tumor cell count at the start of treatment. A rising circulating tumor cell count after three cycles of therapy predicted poor survival, while a decline predicted good survival.
|Keywords||Circulating tumor cells, Docetaxel, Lenalidomide, Metastatic castration-resistant prostate cancer, Prostate cancer|
|Persistent URL||dx.doi.org/10.1016/j.eururo.2016.07.051, hdl.handle.net/1765/108250|
|Journal||European Urology : Official Journal of the European Association of Urology|
Vogelzang, N.J, Fizazi, K, Burke, J.M, de Wit, R, Bellmunt, J, Hutson, T.E. (Thomas E.), … Petrylak, D.P. (2017). Circulating Tumor Cells in a Phase 3 Study of Docetaxel and Prednisone with or without Lenalidomide in Metastatic Castration-resistant Prostate Cancer. European Urology : Official Journal of the European Association of Urology, 71(2), 168–171. doi:10.1016/j.eururo.2016.07.051