Objective: To evaluate renal blood flow and renal volume for the prediction of postnatal renal function in fetuses with solitary functioning kidney (SFK). Methods: Seventy-four SFK fetuses (unilateral renal agenesis [12], multicystic dysplastic kidney [36], and severe renal dysplasia [26]) were compared with 58 healthy fetuses. Peak systolic velocity (PSV), pulsatility index (PI), and resistance index (RI) of the renal artery (RA) were measured; 2D and 3D (VOCAL) volumes were calculated. Renal length and glomerular filtration rate (GFR) were obtained in SFK children (2 years). Results: Compared with the control group, the PSV RA was significantly lower in nonfunctioning kidneys and significantly higher in SFK. Volume measurements indicated a significantly larger volume of SFK compared with healthy kidneys. All but 4 children had GFR above 70 mL/min/1.73 m2, and compensatory hypertrophy was present in 69% at 2 years. PSV RA and SFK volume correlated with postnatal renal hypertrophy. No correlation between prenatal and postnatal SFK volume and GFR at 2 years was demonstrated. Conclusion: Low PSV RA might have a predictive value for diagnosing a nonfunctioning kidney in fetuses with a SFK. We demonstrated a higher PSV RA and larger renal volume in the SFK compared with healthy kidneys.

Additional Metadata
Persistent URL dx.doi.org/10.1002/pd.5167, hdl.handle.net/1765/108307
Journal Prenatal Diagnosis
Citation
Hindryckx, A. (An), Raaijmakers, A. (Anke), Levtchenko, E.N, Allegaert, K.M, & de Catte, L. (2017). Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney. Prenatal Diagnosis, 37(12), 1213–1218. doi:10.1002/pd.5167