Early resection is standard of care for presumed low-grade gliomas. This is based on studies including only tumors that were post-surgically confirmed as low-grade glioma. Unfortunately this does not represent the clinicians’ situation wherein he/she has to deal with a lesion on MRI that is suspect for low-grade glioma (i.e. without prior knowledge on the histological diagnosis). We therefore aimed to determine the optimal initial strategy for patients with a lesion suspect for low-grade glioma, but not histologically proven yet. We retrospectively identified 150 patients with a resectable presumed low-grade-glioma and who were otherwise in good clinical condition. In this cohort we compared overall survival between three types of initital treatment strategy: a wait-and-scan approach (n = 38), early resection (n = 83), or biopsy for histopathological verification (n = 29). In multivariate analysis, no difference was observed in overall survival for early resection compared to wait-and-scan: hazard ratio of 0.92 (95% CI 0.43–2.01; p = 0.85). However, biopsy strategy showed a shorter overall survival compared to wait-and-scan: hazard ratio of 2.69 (95% CI 1.19–6.06; p = 0.02). In this cohort we failed to confirm superiority of early resection over a wait-and-scan approach in terms of overall survival, though longer follow-up is required for final conclusion. Biopsy was associated with shorter overall survival.

Additional Metadata
Keywords Biopsy, Diffuse low-grade glioma, Resection, Survival, Wait-and-scan
Persistent URL dx.doi.org/10.1007/s11060-017-2418-8, hdl.handle.net/1765/108416
Journal Journal of Neuro-Oncology
Wijnenga, M.M.J, Mattni, T. (Tariq), French, P.J, Rutten, G.-J. (Geert-Jan), Leenstra, S, Kloet, F. (Fred), … Vincent, A. (2017). Does early resection of presumed low-grade glioma improve survival? A clinical perspective. Journal of Neuro-Oncology, 133(1), 137–146. doi:10.1007/s11060-017-2418-8