Aim To identify patient and lesion characteristics associated with the occurrence of single or multiple hepatocellular adenoma (HCA).
Patients and methods Using a tertiary centre database, we retrospectively collected information on patient and lesion characteristics, management and follow-up of all patients with HCA included between 2001 and 2016. Patients were classified into three groups; patients with a single HCA, 2-9 HCA and at least 10 HCA.
Results A total of 458 patients were diagnosed with HCA, including 121 (26.4%) with single HCA, 235 (51.3%) with 2-9 HCA and 102 (22.3%) with at least 10 HCA. Significant differences in the mean BMI were found, with the highest BMI in patients with more than 10 HCA (P<0.05). The mean BMI was significantly higher in patients with inflammatory HCA compared with steatotic HCA (31 vs. 26, respectively, P<0.05). Steatotic HCA were more often single lesions (22/55, 40%), whereas patients with inflammatory HCA were often diagnosed with multiple lesions (122/166, 73%).
Conclusion Our series show a significantly higher BMI and frequency of inflammatory HCA in patients with multiple HCA compared with single HCA.

adenoma, disease management, liver, liver cell, liver diseases, obesity,
European Journal of Gastroenterology and Hepatology
Department of Surgery

Bröker, M.E.E, Gaspersz, M.P, Klompenhouwer, A.J, Hansen, B.E, Terkivatan, T, Taimr, P, … IJzermans, J.N.M. (2017). Inflammatory and multiple hepatocellular adenoma are associated with a higher BMI. European Journal of Gastroenterology and Hepatology, 29(10), 1183–1188. doi:10.1097/MEG.0000000000000930