A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death
The implementation of donation after circulatory death category 3 (DCD3) was one of the attempts to reduce the gap between supply and demand of donor lungs. In the Netherlands, the total number of potential lung donors was greatly increased by the availability of DCD3 lungs in addition to the initial standard use of donation after brain death (DBD) lungs. From the three lung transplant centers in the Netherlands, 130 DCD3 recipients were one-to-one nearest neighbor propensity score matched with 130 DBD recipients. The primary end points were primary graft dysfunction (PGD), posttransplant lung function, freedom from chronic lung allograft dysfunction (CLAD), and overall survival. PGD did not differ between the groups. Posttransplant lung function was comparable after bilateral lung transplantation, but seemed worse after DCD3 single lung transplantation. The incidence of CLAD (p = 0.17) nor the freedom from CLAD (p = 0.36) nor the overall survival (p = 0.40) were significantly different between both groups. The presented multicenter results are derived from a national context where one third of the lung transplantations are performed with DCD3 lungs. We conclude that the long-term outcome after lung transplantation with DCD3 donors is similar to that of DBD donors and that DCD3 donation can substantially enlarge the donor pool.
|Keywords||bronchiolitis obliterans (BOS), clinical research/practice, donors and donation: donation after brain death (DBD), donors and donation: donation after circulatory death (DCD), lung (allograft) function/dysfunction, lung transplantation/pulmonology, organ procurement and allocation, organ transplantation in general, patient survival|
|Persistent URL||dx.doi.org/10.1111/ajt.14339, hdl.handle.net/1765/108560|
|Journal||American Journal of Transplantation|
van Suylen, V. (V.), Luijk, B, Hoek, R.A.S, van de Graaf, E.A, Verschuuren, E.A, Van De Wauwer, C. (C.), … Erasmus, M.E. (M. E.). (2017). A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death. American Journal of Transplantation, 17(10), 2679–2686. doi:10.1111/ajt.14339