The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1 of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95 confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition.

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Keywords Aortic valve pathology, calcification, dementia, epidemiology, imaging
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Journal Journal of Alzheimer's Disease
Wolters, F.J, Bos, D, Vernooij, M.W, Franco, O.H, Hofman, A, Koudstaal, P.J, … Ikram, M.A. (2017). Aortic valve calcification and the risk of dementia: A population-based study. Journal of Alzheimer's Disease, 55(3), 893–897. doi:10.3233/JAD-160871