2017
Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults
Publication
Publication
Head & Neck: journal for the sciences and specialities of the head and neck , Volume 39 - Issue 1 p. 140- 146
Background: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck. Methods: All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed. Results: We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively). Conclusion: In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy.
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| doi.org/10.1002/hed.24556, hdl.handle.net/1765/108684 | |
| Head & Neck: journal for the sciences and specialities of the head and neck | |
| Organisation | Department of Medical Oncology |
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Boon, E. (Eline), van der Graaf, W., Gelderblom, H., Tesselaar, M.E.T. (Margot E. T.), van Es, R., Oosting, S., … Herpen, C. (2017). Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults. Head & Neck: journal for the sciences and specialities of the head and neck, 39(1), 140–146. doi:10.1002/hed.24556 |
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