Autoimmune hepatitis (AIH) develops in genetically predisposed individuals after an inciting or environmental trigger. These factors are unknown but may include viral infections, environmental toxins, drugs and vaccinations. Few reports are written about vaccination as potential trigger of autoimmune hepatitis. In this article, we additionally describe two vaccine-related cases of AIH. In both cases, long-term immune-suppressive therapy is demanded. Moreover, we present the cases of vaccine-related AIH from literature and compare these with idiopathic AIH and our own cases.

autoimmune hepatitis, autoimmunity, Hepatitis A virus, vaccination
dx.doi.org/10.1080/00365521.2016.1224379, hdl.handle.net/1765/108694
Scandinavian Journal of Gastroenterology
Erasmus MC: University Medical Center Rotterdam

van Gemeren, M.A.J. (Marline A J), van Wijngaarden, P, Doukas, M. (Michael), & de Man, R.A. (2017). Vaccine-related autoimmune hepatitis: the same disease as idiopathic autoimmune hepatitis? Two clinical reports and review. Scandinavian Journal of Gastroenterology, 52(1), 18–22. doi:10.1080/00365521.2016.1224379