This study reveals that 1918 H1N1 influenza virus spreads to and induces proinflammatory cytokine responses in extrarespiratory tissues, including the nervous system, liver, and heart. This likely contributes to the development of severe disease, including diseases of the nervous system.

1918 H1N1 virus, CNS disease, extrarespiratory, influenza A virus, pathogenesis
dx.doi.org/10.1093/infdis/jiy003, hdl.handle.net/1765/108744
The Journal of Infectious Diseases
Department of Virology

de Wit, E, Siegers, J.Y, Cronin, J.M. (Jacqueline M.), Weatherman, S. (Sarah), van den Brand, J.M.A, Leijten, L.M.E, … van Riel, D.A.J. (2018). 1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets. The Journal of Infectious Diseases, 217(8), 1237–1246. doi:10.1093/infdis/jiy003