1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets

de Wit, Emmie; Siegers, Jurre; Cronin, Jacqueline M.; Weatherman, Sarah; van den Brand, Judith; Leijten, Lonneke; van Run, Peter; Begeman, Lineke; van den Ham, H.J.; Andeweg, Arno; Bushmaker, Trenton; Scott, Dana P.; Saturday, Greg; Munstert, Vincent; Feldmann, Heinz; van Riel, Debby

doi:10.1093/infdis/jiy003

This study reveals that 1918 H1N1 influenza virus spreads to and induces proinflammatory cytokine responses in extrarespiratory tissues, including the nervous system, liver, and heart. This likely contributes to the development of severe disease, including diseases of the nervous system.

Additional Metadata
Keywords	1918 H1N1 virus, CNS disease, extrarespiratory, influenza A virus, pathogenesis
Persistent URL	doi.org/10.1093/infdis/jiy003, hdl.handle.net/1765/108744
Journal	The Journal of Infectious Diseases
Organisation	Department of Virology
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	de Wit, E., Siegers, J., Cronin, J.M. (Jacqueline M.), Weatherman, S. (Sarah), van den Brand, J., Leijten, L., … van Riel, D. (2018). 1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets. The Journal of Infectious Diseases, 217(8), 1237–1246. doi:10.1093/infdis/jiy003

1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets

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1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets

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