Purpose: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate. Method: Interventional case report. Results: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed. Conclusions: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

Eyelids, IgG4-related disease, Orbital, Tarsus
dx.doi.org/10.1007/s10792-018-0974-3, hdl.handle.net/1765/108986
International Ophthalmology
no subscription
Department of Internal Medicine

Verhoekx, J.S.N, Karim, A.F, van Laar, J.A.M, Verdijk, R.M, & Paridaens, A.D.A. (2018). The tarsal plate manifestation of IgG4-related disease. International Ophthalmology, 1–3. doi:10.1007/s10792-018-0974-3