We read with interest the results of the pilot study in England, which was performed to establish the acceptability and diagnostic performance of screening with the faecal immunochemical test (FIT) over the guaiac faecal occult blood test (gFOBT).1 When comparing gFOBT to FIT, the uptake increased from 59.4% to 66.4%, positivity rate increased from 1.7% to 7.8% (at a cut-off level of 20 μg Hb/g faeces) and colorectal cancer (CRC) detection doubled. Moreover, this report showed that also with FIT cut-off levels above 20 μg Hb/g faeces, improved clinical outcomes can be achieved over gFOBT. However, for a screening programme to be effective, it is a prerequisite to detect cancers in an early stage. Thus far, information on stage distribution of screen-detected CRCs in a population-based FIT screening programme is lacking. [...]

Additional Metadata
Keywords colorectal cancer, colorectal cancer screening, staging
Persistent URL dx.doi.org/10.1136/gutjnl-2017-315111, hdl.handle.net/1765/109125
Journal Gut (English Edition): an international journal of gastroenterology & hepatology
Citation
Toes-Zoutendijk, E, Kooyker, A.I, Elferink, M.A.G, Spaander, M.C.W, Dekker, E, de Koning, H.J, … Lansdorp-Vogelaar, I. (2017). Stage distribution of screen-detected colorectal cancers in the Netherlands. Gut (English Edition): an international journal of gastroenterology & hepatology. doi:10.1136/gutjnl-2017-315111