Pharmacokinetics of colistin in patients with multidrug-resistant gram-negative infections: A pilot study
Background & objectives: There is little information concerning intravenously (i.v.) administered colistin in patients with multidrug-resistant (MDR) Gram-negative infections. Thus, this pilot prospective study was undertaken to characterize efficacy and pharmacokinetics of colistin in patients with MDR Gram-negative infections. Methods: Nine patients with age >12 yr and MDR Gram-negative infections were included, of whom six were given colistin at the doses of 2 MU, while three patients were given 1 MU i.v. dose every 8 h. Blood samples were collected at different time intervals. Determination of colistin concentration was done by a ultra-high-performance liquid chromatography/mass spectrometry/selected reaction monitoring assay. Results: The area under the plasma concentration-versus-time curve over eight hours (AUC0-8) for colistin after the 1st dose ranged from 3.3 to 16.4 mg×h/l (median, 4.59). After the 5th dose, AUC0-8 for colistin ranged from 4.4 to 15.8 mg×h/l (median, 6.0). With minimal inhibitory concentration (MIC) value of 0.125 mg/l, AUC0-8/MIC ranged from 26.7 to 131.4 (median, 36.7) and 35.5 to 126.0 (median, 48.0) after the 1st and the 5th doses of 2 MU every 8 h, respectively. Interpretation & conclusions: As there is a paucity of information on AUC/MIC for colistin, it may not be possible to conclude whether AUC/MIC values in our patients were adequate. There is a microbiological clearance of organism, which goes in favour of the dosing schedule being adequate. Further studies need to be done to understand the pharmacokinetics of colistin in patients with infections.
|Keywords||Colistin, Gram-negative infections, MDR, Pharmacodynamics, Pharmacokinetics|
|Persistent URL||dx.doi.org/10.4103/ijmr.IJMR_1464_16, hdl.handle.net/1765/109434|
|Journal||The Indian Journal of Medical Research|
Gautam, V. (Vikas), Shafiq, N. (Nusrat), Mouton, J.W, Malhotra, S. (Sameer), Kaur, S. (Satinder), & Ray, P. (Pallab). (2018). Pharmacokinetics of colistin in patients with multidrug-resistant gram-negative infections: A pilot study. The Indian Journal of Medical Research, 147(April), 407–412. doi:10.4103/ijmr.IJMR_1464_16