Objective: To determine the incidence of refractory anastomotic strictures after oesophageal atresia (OA) repair and to identify risk factors associated with refractory strictures.
Methods: Retrospective national multicentre study in patients with OA born between 1999 and 2013. Exclusion criteria were isolated fistula, inability to obtain oesophageal continuity, death prior to discharge and follow-up <6 months. A refractory oesophageal stricture was defined as an anastomotic stricture requiring ≥5 dilations at maximally 4-week intervals. Risk factors for development of refractory anastomotic strictures after OA repair were identified with multivariable logistic regression analysis.
Results: We included 454 children (61% male, 7% isolated OA (Gross type A)). End-to-end anastomosis was performed in 436 (96%) children. Anastomotic leakage occurred in 13%. Fifty-eight per cent of children with an end-to-end anastomosis developed an anastomotic stricture, requiring a median of 3 (range 1-34) dilations. Refractory strictures were found in 32/436 (7%) children and required a median of 10 (range 5-34) dilations. Isolated OA (OR 5.7; p=0.012), anastomotic leakage (OR 5.0; p=0.001) and the need for oesophageal dilation ≤28 days after anastomosis (OR 15.9; p<0.001) were risk factors for development of a refractory stricture.
Conclusions: The incidence of refractory strictures of the end-to-end anastomosis in children treated for OA was 7%. Risk factors were isolated OA, anastomotic leakage and the need for oesophageal dilation less than 1 month after OA repair.

Additional Metadata
Keywords oesophageal atresia, oesophageal dilation procedures, oesophageal strictures, outcome, risk factors
Persistent URL dx.doi.org/10.1136/archdischild-2017-314710, hdl.handle.net/1765/109500
Journal Archives of Disease in Childhood
Citation
Vergouwe, F.W.T, Vlot, J, IJsselstijn, H, Spaander, M.C.W, van Rosmalen, J.M, Oomen, M.W, … Wijnen, R.M.H. (2018). Risk factors for refractory anastomotic strictures after oesophageal atresia repair. Archives of Disease in Childhood. doi:10.1136/archdischild-2017-314710