Air pollution and airway resistance at age 8 years - The PIAMA birth cohort study
Background: Air pollution has been found to adversely affect children’s lung function. Forced expiratory volume in 1 s and forced vital capacity from spirometry have been studied most frequently, but measurements of airway resistance may provide additional information. We assessed associations of long-term air pollution exposure with airway resistance. Methods: We measured airway resistance at age 8 with the interrupter resistance technique (Rint) in participants of the Dutch PIAMA birth cohort study. We linked Rint with estimated annual average air pollution concentrations [nitrogen oxides (NO2, NOx), PM2.5 absorbance (“soot”), and particulate matter < 2.5 μm (PM2.5), < 10 μm (PM10) and 2.5-10 μm (PMcoarse)] at the birth address and current home address (n = 983). Associations between air pollution exposure and interrupter resistance (Rint) were assessed using multiple linear regression adjusting for potential confounders. Results: We found that higher levels of NO2 at the current address were associated with higher Rint [adj. mean difference (95% confidence interval) per interquartile range increase in NO2: 0.018 (0.001, 0.035) kPa·s·L− 1]. Similar trends were observed for the other pollutants, except, PM10. No association was found between Rint and exposure at the birth address. Conclusions: Our results support the hypothesis that air pollution exposure is associated with a lower lung function in schoolchildren.
|Keywords||Air pollution, Children, Interrupter resistance, Nitrogen dioxide, Particulate matter|
|Persistent URL||dx.doi.org/10.1186/s12940-018-0407-9, hdl.handle.net/1765/109502|
|Journal||Environmental Health: A Global Access Science Source|
Finke, I. (Isabelle), de Jongste, J.C, Smit, H.A, Wijga, A.H, Koppelman, G.H, Vonk, J.M, … Gehring, U. (2018). Air pollution and airway resistance at age 8 years - The PIAMA birth cohort study. Environmental Health: A Global Access Science Source, 17(1), 1–10. doi:10.1186/s12940-018-0407-9