Background: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up. Material and Methods: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 – 70 years, 71 – 75 years, and >75 years. The study period extended over 30 years, divided in three decades. Multivariate survival analysis was carried out using Cox regression analysis. Results: The two youngest age categories showed significant improvements over time in 12-year DMFS and DSS. For women aged 65 – 70 years, this improvement was noted in stage I and stage II disease, while for women aged 71 – 75 years this was mainly in stage II tumors. Women >75 years of age did not show any improvement over time, regardless of stage. Conclusion: Among older Dutch women with breast cancer, outcomes with regard to DMFS and DSS after BCT differ between various age categories, showing the least gain in the very old.

Breast neoplasms, Breast-conserving therapy, Cohort study, Older adults, Survival analyses,
Journal of Geriatric Oncology
Department of Radiation Oncology

Jobsen, J.J, Middelburg, J.G, van der Palen, J, Riemersma, S, Siemerink, E. (Ester), Struikmans, H, & Siesling, S. (2018). Breast-conserving therapy in older patients with breast cancer over three decades: progress or stagnation. Journal of Geriatric Oncology. doi:10.1016/j.jgo.2018.08.007