Risk Factors and Transmission of Healthcare-Related Pathogens
Risicofactoren voor en overdracht van zorggerelateerde ziekteverwekkers
The literature reviews and observational studies in this thesis are about the role of epidemiology in describing, identifying and controlling transmission of healthcare-related pathogens. The ultimate goal of conducting these studies is to optimize care and to provide safer care for patients admitted to the Erasmus MC.
In chapter 2 three literature reviews are described about (i) ESBL-producing Klebsiella species, (ii) carbapenem-producing Enterobacteriaceae and (iii) VIM-positive Pseudomonas aeruginosa. The most important risk factors, effective infection prevention strategies and sources have been identified.
In chapter 3 the theoretical knowledge from the systematic reviews has been applied in different outbreak scenarios in the Erasmus MC.
(i) A case-control study on a long-lasting outbreak of VIM-positive P. aeruginosa.
(ii) A nationwide study about contamination of duodenoscopes; following an outbreak report on a duodenoscope as source of VIM-positive P. aeruginosa published by Verfaillie et al. (Endoscopy 2015, 47:493-502)
(iii) An outbreak investigation of a Clostridium difficile outbreak at a gastro-intestinal surgical ward.
Finally, in chapter 4 the role of epidemiology when using genotypic and phenotypic typing techniques is described, (i) for ESBL-producing Klebsiella species, and (ii) for ESBL-producing Escherichia coli.
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|M.C. Vos (Margreet) , J.A. Severin (Juliëtte)|
|Erasmus University Rotterdam|
|Organisation||Department of Medical Microbiology and Infectious Diseases|