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Elliott, P. (Paul)
and
M. Caulfield (Mark)
2018-09-17
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Publication
Publication
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Additional Metadata | |
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Persistent URL | doi.org/10.1038/s41588-018-0205-x, hdl.handle.net/1765/110487 |
Journal | Nature Genetics |
Grant | This work was funded by the European Commission 7th Framework Programme; grant id h2020/661395 - Moving from genome wide association to elucidating causal mechanisms of electrocardiographic traits (MOvE-ECG), This work was funded by the European Commission 7th Framework Programme; grant id h2020/654241 - PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data (PhenoMeNal) |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Citation |
Evangelou, E., Warren, H., Mosen-Ansorena, D. (David), Mifsud, B. (Borbala), Pazoki, R. (Raha), Gao, H. (He), … Caulfield, M. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. doi:10.1038/s41588-018-0205-x |