This thesis aimed to identify genomic and metabolomic determinants of neurological and psychiatric disorders and their related endophenotypes by making use of various omics approaches.

Novel insights into the pathophysiology of these disorders are provided by identifying novel genetic determinants underlying brain structures, cognitive ability, and neurodevelopmental disorders.
Furthermore, a link between circulating metabolites and neurovascular pathology or gut microbiota is also highlighted.

Genomics, omics, neurodegeneration, neurovascular pathology, psychiatric diseases
C.M. van Duijn (Cornelia)
Erasmus University Rotterdam
hdl.handle.net/1765/110570
Department of Epidemiology

Vojinović, D. (2018, December 12). Genomic and Metabolomic Determinants of Neurological and Psychiatric Traits. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/110570

Additional Files
Cover-Vojinovic.PNG Cover Image , 115kb
Stellingen.pdf , 523kb
110570_Chapter_1-General_introduction.pdf Final Version , 2mb
110570_Chapter_2_1-Genome-wide_association_study_of_23-50.pdf Final Version , 2mb
110570_Chapter_2_2-Genetic_determinants_of_general_cognit.pdf Final Version , 1mb
110570_Chapter_2_3-Meta-analysis_of_epigenome-wide_associ.pdf Final Version , 741kb
110570_Chapter_2_4-The_dystrophin_gene_and_cognitive_func.pdf Final Version , 1mb
110570_Chapter_2_5-Intellectual_ability_in_the_Duchenne_m.pdf Final Version , 253kb
110570_Chapter_3_1-Whole-genome_linkage_scan_combined_wit.pdf Final Version , 1mb
110570_Chapter_3_2-Metabolic_profiling_of_intra-_and_extr.pdf Final Version , 1mb
110570_Chapter_3_3-Circulating_metabolites_and_risk_of_st.pdf Final Version , 1mb
110570_Chapter_3_4-Relationship_between_gut_microbiota_an.pdf Final Version , 2mb
110570_Chapter_4_1-Variants_in_TTC25_affect_autistic_trai.pdf Final Version , 398kb
110570_Chapter_4_2-STXBP5_Antisense_RNA_1_gene_and_adult.pdf Final Version , 5mb
110570_Chapter_5_1-Findings_Of_This_Thesis.pdf Final Version , 1mb
110570_Chapter_5_2-A_model_for_mass_personalization_in_ca.pdf Final Version , 235kb
110570_Chapter_6-Summary_Samenvatting.pdf Final Version , 131kb
110570_Chapter_7_1-Acknowledgements_Dankwoord.pdf Final Version , 126kb
110570_Chapter_7_2-PhD_Portfolio.pdf Final Version , 121kb
110570_Chapter_7_3-List_of_publications_and_manuscripts.pdf Final Version , 169kb
110570_Chapter_7_4-About_the_author.pdf Final Version , 574kb