Anttila, V. (Verneri),
B.K. Bulik-Sullivan (Brendan),
H.K. Finucane (Hilary K.),
R.K. Walters (Raymond),
Bras, J. (Jose),
Duncan, L. (Laramie),
Escott-Price, V. (Valentina),
G.J. Falcone (Guido J.),
A.M. Gormley,
R. Malik (Rainer),
et al.
N.A. Patsopoulos (Nikolaos),
S. Ripke (Stephan),
Wei, Z. (Zhi),
D. Yu (D.),
Lee, P.H. (Phil H.),
P. Turley (Patrick),
B. Grenier-Boley (Benjamin),
Chouraki, V. (Vincent),
Y. Kamatani (Yoichiro),
C. Berr (Claudine),
L. Letenneur,
D. Hannequin (Didier),
P. Amouyel (Philippe),
Boland, A. (Anne),
J.-F. Deleuze (Jean-François),
Duron, E. (Emmanuelle),
B.N. Vardarajan (Badri),
C. Reitz (Christiane),
Goate, A.M. (Alison M.),
Huentelman, M.J. (Matthew J.),
M.I. Kamboh (M. Ilyas),
Larson, E.B. (Eric B.),
E. Rogaeva (Ekaterina),
George-Hyslop, P.S. (Peter St),
H. Hakonarson (Hakon),
W.A. Kukull,
L.A. Farrer (Lindsay),
Barnes, L.L. (Lisa L.),
T.G. Beach (Thomas),
Yesim Demirci, F. (F.),
Head, E. (Elizabeth),
Hulette, C.M. (Christine M.),
Jicha, G.A. (Gregory A.),
Kauwe, J.S.K. (John S.K.),
Kaye, J.A. (Jeffrey A.),
Leverenz, J.B. (James B.),
A.I. Levey (Allan),
Lieberman, A.P. (Andrew P.),
V.S. Pankratz (Shane),
Poon, W.W. (Wayne W.),
Quinn, J.F. (Joseph F.),
Saykin, A.J. (Andrew J.),
Schneider, L.S. (Lon S.),
Smith, A.G. (Amanda G.),
Sonnen, J.A. (Joshua A.),
Stern, R.A. (Robert A.),
V.M. Deerlin (Vivianna),
Van Eldik, L.J. (Linda J.),
Harold, D. (Denise),
Russo, G. (Giancarlo),
D.C. Rubinsztein (David),
Bayer, A. (Anthony),
M. Tsolaki (Magda),
Proitsi, P. (Petra),
N.C. Fox (Nick),
Hampel, H. (Harald),
M.J. Owen (Michael),
Mead, S. (Simon),
Passmore, P. (Peter),
Morgan, K. (Kevin),
M.M. Nöthen (Markus),
M. Rossor (Martin),
M.K. Lupton (Michelle),
P. Hoffmann (Per),
J. Kornhuber (Johannes),
B.A. Lawlor (B.),
McQuillin, A. (Andrew),
Al-Chalabi, A. (Ammar),
J.C. Bis (Joshua),
A. Ruiz (A.),
Boada, M. (Mercè),
S. Seshadri (Sudha),
A. Beiser (Alexa),
K.M. Rice (Kenneth),
S.J. van der Lee (Sven),
De Jager, P.L. (Philip L.),
H. Geschwind,
Riemenschneider, M. (Matthias),
S. Riedel-Heller (Steffi),
J.I. Rotter (Jerome I.),
Ransmayr, G. (Gerhard),
B.T. Hyman (Bradley),
C. Cruchaga (Carlos),
M. Alegret (M.),
Winsvold, B. (Bendik),
P. Palta (Priit),
K.-H. Farh (Kai-How),
Cuenca-Leon, E. (Ester),
Furlotte, N. (Nicholas),
T. Kurth (Tobias),
L. Ligthart (Lannie),
G.M. Terwindt (Gisela),
B. Müller-Myhsok (Bertram),
Ran, C. (Caroline),
S.D. Gordon (Scott D.),
H. Göbel (Hartmut),
H.H.H. Adams (Hieab),
T. Lehtimäki (Terho),
Wedenoja, J. (Juho),
Buring, J.E. (Julie E.),
M. Schürks (Markus),
Hrafnsdottir, M. (Maria),
J.J. Hottenga (Jouke Jan),
B.W.J.H. Penninx (Brenda),
V. Artto (Ville),
E. Hämäläinen (Eija),
S. Lucae (Susanne),
Martin, N.G. (Nicholas G.),
Montgomery, G.W. (Grant W.),
Kurki, M.I. (Mitja I.),
E. Hämäläinen (Eija),
Huang, H. (Hailiang),
J. Huang (Jian),
Sandor, C. (Cynthia),
Webber, C. (Caleb),
B. Müller-Myhsok (B.),
Schreiber, S. (Stefan),
V. Salomaa (Veikko),
E. Loehrer (Elizabeth),
S. Steinberg (Stacy),
A. MacAya (Alfons),
P. Pozo-Rosich (Patricia),
T. Hansen (Thomas),
T.M. Werge (Thomas),
Kaprio, J. (Jaakko),
Metspalu, A. (Andres),
C. Kubisch (Christian),
M.D. Ferrari (Michel),
Belin, A.C. (Andrea C.),
A.M.J.M. Maagdenberg (Arn),
J-A. Zwart (John-Anker),
D.I. Boomsma (Dorret),
Eriksson, N. (Nicholas),
J. Olesen (Jes),
D.I. Chasman (Daniel),
D.R. Nyholt (Dale),
Avbersek, A. (Andreja),
Baum, L. (Larry),
S.F. Berkovic (Samuel),
J.P. Bradfield (Jonathan),
Buono, R. (Russell),
C.F.B.S. Catarino,
Cossette, P. (Patrick),
P. de Jonghe (P.),
C. Depondt (Chantal),
Dlugos, D. (Dennis),
Ferraro, T.N. (Thomas N.),
French, J. (Jacqueline),
Hjalgrim, H. (Helle),
Jamnadas-Khoda, J. (Jennifer),
R. Kälviäinen,
W.S. Kunz (Wolfram S.),
Lerche, H. (Holger),
Leu, C. (Costin),
D. Lindhout (Dick),
Lo, W. (Warren),
Lowenstein, D. (Daniel),
M. Mccormack (Mark),
R.S. Møller (Rikke),
A. Molloy (A.),
Ng, P.-W. (Ping-Wing),
Oliver, K. (Karen),
Privitera, M. (Michael),
Radtke, R. (Rodney),
A.-K. Ruppert (Ann-Kathrin),
Sander, T. (Thomas),
Schachter, S. (Steven),
Schankin, C. (Christoph),
Scheffer, I. (Ingrid),
S. Schoch (Susanne),
S.M. Sisodiya (Sanjay),
Smith, P. (Philip),
Sperling, M. (Michael),
P. Striano (Pasquale),
Surges, R. (Rainer),
Neil Thomas, G. (G.),
Visscher, F. (Frank),
C.D. Whelan (Christopher),
F. Zara (Federico),
Heinzen, E.L. (Erin L.),
Marson, A. (Anthony),
Becker, F. (Felicitas),
H. Stroink (Hans),
Zimprich, F. (Fritz),
Gasser, T. (Thomas),
J. Gibbs (Raphael),
P. Heutink (Peter),
Martinez, M. (Maria),
H. Morris (Huw),
Sharma, M. (Manu),
Ryten, M. (Mina),
K. Mok (Kin),
S.L. Pulit (Sara),
S. Bevan (Steve),
Holliday, E. (Elizabeth),
Attia, J. (John),
T.W.K. Battey (Thomas W. K.),
G. Boncoraglio (Giorgio Battista),
Thijs, V. (Vincent),
Chen, W.-M. (Wei-Min),
Mitchell, B. (Braxton),
P.M. Rothwell (Peter),
Sharma, P. (Pankaj),
C. Sudlow (Cathie),
A.M. Vicente (Astrid M),
Markus, H. (Hugh),
Kourkoulis, C. (Christina),
Pera, J. (Joana),
Raffeld, M. (Miriam),
S.L. Silliman (Scott L.),
Perica, V.B. (Vesna Boraska),
Thornton, L.M. (Laura M.),
Huckins, L.M. (Laura M.),
N.W. Rayner (Nigel William),
Lewis, C.M. (Cathryn M.),
Gratacos, M. (Monica),
Rybakowski, F. (Filip),
Keski-Rahkonen, A. (Anna),
Raevuori, A. (Anu),
Hudson, J.I. (James I.),
Reichborn-Kjennerud, T. (Ted),
Monteleone, P. (Palmiero),
Karwautz, A. (Andreas),
Mannik, K. (Katrin),
Baker, J.H. (Jessica H.),
O'Toole, J.K. (Julie K.),
Trace, S.E. (Sara E.),
O.S.P. Davis (Oliver S.),
Helder, S.G. (Sietske G.),
S.M. Ehrlich (Stefan),
Herpertz-Dahlmann, B. (Beate),
Danner, U.N. (Unna N.),
A.A. van Elburg (Annemarie),
M. Clementi (Maurizio),
Forzan, M. (Monica),
Docampo, E. (Elisa),
Lissowska, J. (Jolanta),
J. Hauser (J.),
Tortorella, A. (Alfonso),
Maj, M. (Mario),
Gonidakis, F. (Fragiskos),
Tziouvas, K. (Konstantinos),
Papezova, H. (Hana),
Yilmaz, Z. (Zeynep),
Wagner, G. (Gudrun),
Cohen-Woods, S. (Sarah),
S. Herms (Stefan),
Julia, A. (Antonio),
Rabionet, R. (Raquel),
D.M. Dick (Danielle),
S. Ripatti (Samuli),
Andreassen, O.A. (Ole A.),
T. Espeseth (Thomas),
A.J. Lundervold (Astri),
V.M. Steen (Vidar),
D. Pinto (Duane),
Scherer, S.W. (Stephen W.),
Aschauer, H. (Harald),
Schosser, A. (Alexandra),
L. Alfredsson (Lars),
L. Padyukov (L.),
Halmi, K.A. (Katherine A.),
Mitchell, J. (James),
Strober, M. (Michael),
A.W. Bergen (Andrew),
Kaye, W. (Walter),
J.P. Szatkiewicz (Jin P.),
B. Cormand (Bru),
J.A. Ramos-Quiroga (Josep Antoni),
Sánchez-Mora, C. (Cristina),
M. Ribasés (Marta),
Casas, M. (Miguel),
Hervas, A. (Amaia),
M.J. Arranz (María Jesús),
Haavik, J. (Jan),
Zayats, T. (Tetyana),
Johansson, S. (Stefan),
Williams, N. (Nigel),
Dempfle, A. (Astrid),
D. Rothenberger,
J. Kuntsi (Jonna),
R.D. Oades (Robert D),
T. Banaschewski (Tobias),
B. Franke (Barbara),
J.K. Buitelaar (Jan),
A.A. Vásquez (Arias),
A.E. Doyle (Alysa E),
Reif, A. (Andreas),
Lesch, K.-P. (Klaus-Peter),
C.M. Freitag (Christine),
Rivero, O. (Olga),
Palmason, H. (Haukur),
Romanos, M. (Marcel),
Langley, K. (Kate),
M. Rietschel (Marcella),
S.H. Witt (Stephanie H),
Dalsgaard, S. (Soeren),
A.D. Borglum (Anders),
Waldman, I. (Irwin),
Wilmot, B. (Beth),
Molly, N. (Nikolas),
Bau, C.H.D. (Claiton H.D.),
J. Crosbie (Jennifer),
R. Schachar (Russell),
Loo, S.K. (Sandra K.),
McGough, J.J. (James J.),
Grevet, E.H. (Eugenio H.),
Medland, S.E. (Sarah E.),
Robinson, E. (Elise),
Weiss, L.A. (Lauren A.),
Bacchelli, E. (Elena),
A.J. Bailey (Anthony),
Bal, V. (Vanessa),
F.C. Battaglia (Frederick),
C. Betancur (Catalina),
Bolton, P. (Patrick),
R.M. Cantor,
Celestino-Soper, P. (Patrícia),
Dawson, G. (Geraldine),
S. de Rubeis (Silvia),
Duque, F. (Frederico),
A.J. Green (Andrew J.),
S.M. Klauck (Sabine M),
M. Leboyer (Marion),
Levitt, P. (Pat),
E. Maestrini (Elena),
S. Mane (Shrikant),
D. Moreno-De-Luca (Daniel),
Parr, J. (Jeremy),
R. Regan (Regina),
A. Reichenberg (Abraham),
Sandin, S. (Sven),
J.A.S. Vorstman,
A.M.J. Wassink (Annemarie),
E.M. Wijsman (Ellen),
E.H. Cook (Edwin H),
S. Santangelo,
R. Delorme (Richard),
Roge, B. (Bernadette),
Magalhaes, T. (Tiago),
D.E. Arking (Dan),
T.G. Schulze (Thomas),
R.C. Thompson (Robert C),
Strohmaier, J. (Jana),
Matthews, K. (Keith),
I. Melle (Ingrid),
Morris, D. (Derek),
D.H.R. Blackwood (Douglas),
McIntosh, A. (Andrew),
S.E. Bergen (Sarah),
M. Schalling (Martin),
S. Jamain (Stéphane),
Maaser, A. (Anna),
Fischer, S.B. (Sascha B.),
Reinbold, C.S. (Céline S.),
Fullerton, J.M. (Janice M.),
Guzman-Parra, J. (José),
Mayoral, F. (Fermin),
Schofield, P.R. (Peter R.),
S. Cichon (Sven),
Mühleisen, T.W. (Thomas W.),
F. Degenhardt,
Schumacher, J. (Johannes),
Bauer, M. (Michael),
Mitchell, P.B. (Philip B.),
E.S. Gershon (Elliot S),
J.P. Rice (John),
Potash, J.B. (James B.),
P.P. Zandi (Peter P),
N.J. Craddock (Nick),
Nicol Ferrier, I. (I.),
M. Alda (Martin),
Rouleau, G.A. (Guy A.),
Turecki, G. (Gustavo),
R.A. Ophoff (Roel),
C. Pato (Carlos),
A. Anjorin (Adebayo),
Stahl, E. (Eli),
I. Leber (Isabelle),
P.M. Czerski,
Cruceanu, C. (Cristiana),
I. Jones,
D. Posthuma (Danielle),
Andlauer, T.F.M. (Till F.M.),
A.J. Forstner (Andreas),
F. Streit (Fabian),
Baune, B.T. (Bernhard T.),
Air, T. (Tracy),
Sinnamon, G. (Grant),
Wray, N.R. (Naomi R.),
D.J. Macintyre (Donald J),
D.J. Porteous (David J.),
G. Homuth (Georg),
Rivera, M. (Margarita),
J. Grove (Jakob),
C.M. Middeldorp (Christel),
I.B. Hickie (Ian),
M.L. Pergadia (Michele),
D. Mehta (Divya),
A.V. Smith (Davey),
Jansen, R. (Rick),
E.J.C. de Geus (Eco),
E.C. Dunn (Erin C.),
Li, Q.S. (Qingqin S.),
M. Nauck (Matthias),
R. Schoevers (Robert),
A.T.F. Beekman (Aartjan),
J.A. Knowles (James A),
A. Viktorin (Alexander),
Arnold, P. (Paul),
C.L. Barr (Cathy),
Bedoya-Berrio, G. (Gabriel),
Joseph Bienvenu, O. (O.),
Brentani, H. (Helena),
Burton, C. (Christie),
B. Camarena (Beatriz),
C. Cappi (Carolina),
D. Cath (Daniëlle),
Cavallini, M. (Maria),
D. Cusi (Daniele),
Darrow, S. (Sabrina),
D.A.J.P. Denys (Damiaan),
E.M. Derks (Eske),
A. Dietrich (Andrea),
T.V. Fernandez (Thomas),
Figee, M. (Martijn),
N.B. Freimer (Nelson),
Gerber, G. (Gloria),
Grados, M. (Marco),
Greenberg, E. (Erica),
Hanna, G.L. (Gregory L.),
Hartmann, A. (Andreas),
M.E. Hirschtritt (Matthew E.),
P.J. Hoekstra (Pieter),
Huang, A. (Alden),
J. Huyser (Jochanan),
C. Illmann (Cornelia),
M.A. Jenike (Michael),
Kuperman, S. (Samuel),
Leventhal, B. (Bennett),
C. Lochner (Christine),
H.N. Lyon (Helen),
F. Macciardi (Fabio),
Madruga-Garrido, M. (Marcos),
Malaty, I.A. (Irene A.),
A. Maras (Athanasios),
L.M. McGrath,
E.C. Miguel (Euripedes),
Mir, P. (Pablo),
G. Nestadt (Gerald),
Nicolini, H. (Humberto),
Okun, M.S. (Michael S.),
A.J. Pakstis,
Paschou, P. (Peristera),
J. Piacentini (John),
C. Pittenger (Christopher),
Plessen, K. (Kerstin),
Ramensky, V. (Vasily),
Ramos, E.M. (Eliana M.),
V.I. Reus (Victor),
M.A. Richter (Margaret),
Riddle, M.A. (Mark A.),
M.M. Robertson,
V. Rœssner (Veit),
Rosário, M. (Maria),
Samuels, J.F. (Jack F.),
P. Sandor (Paul),
D.J. Stein (Dan),
Tsetsos, F. (Fotis),
F. van Nieuwerburgh (Filip),
Weatherall, S. (Sarah),
A. Wendland (Annika),
T. Wolanczyk (Tomasz),
Worbe, Y. (Yulia),
Zai, G. (Gwyneth),
Goes, F.S. (Fernando S.),
McLaughlin, N. (Nicole),
Nestadt, P.S. (Paul S.),
H.J. Grabe (Hans Jörgen),
Depienne, C. (Christel),
A.I. Konkashbaev (Anuar),
N. Lanzagorta (Nuria),
Valencia-Duarte, A. (Ana),
E. Bramon (Elvira),
N.G. Buccola (Nancy G),
W. Cahn (Wiepke),
M.J. Cairns (Murray J.),
Chong, S.A. (Siow A.),
Cohen, D. (David),
B. Crespo-Facorro (Benedicto),
J.J. Crowley (James),
M.W. Davidson (Michael ),
L.E. Delisi (Lynn),
Dinan, T. (Timothy),
D.J. Donohoe (Dennis),
E. Drapeau (Elodie),
J. Duan (Jubao),
L. de Haan (Lieuwe),
D.M. Hougaard (David),
Karachanak-Yankova, S. (Sena),
A. Khrunin (Andrey),
J. Klovins (Janis),
V. Kučinskas (Vaidutis),
J.L.C. Keong (Jimmy Lee Chee),
Limborska, S. (Svetlana),
C.M. Loughland (Carmel),
J. Lönnqvist (Jouko),
B.S. Maher (Brion),
M. Mattheisen (Manuel),
C. McDonald (Colm),
Murphy, K.C. (Kieran C.),
I. Nenadic (Igor),
J. van Os (Jim),
C. Pantelis (Christos),
C. Pato (Carlos),
Petryshen, T. (Tracey),
D.J. Quested (Digby J),
A. Roussos (Alexandra),
A.R. Sanders (Alan),
J.D. Schall (Jeffrey),
Schwab, S.G. (Sibylle G.),
Sim, K. (Kang),
H.-C. So (Hon-Cheong),
E. Stogmann (Elisabeth),
Subramaniam, M. (Mythily),
D. Toncheva (Draga),
J. Waddington (Joanne),
J.T. Walters (James),
M. Weiser (Mark),
W. Cheng (Wei),
Cloninger, R. (Robert),
Curtis, D. (David),
P.V. Gejman (Pablo),
F.A. Henskens (Frans),
M. Mattingsdal (Morten),
S.-Y. Oh (Sang-Yun),
Scott, R. (Rodney),
Webb, B. (Bradley),
G. Breen (Gerome),
C. Churchhouse (Claire),
Bulik, C.M. (Cynthia M.),
Daly, M. (Mark),
C. Kubisch (Christian),
Faraone, S.V. (Stephen V.),
Guerreiro, R. (Rita),
P.A. Holmans (Peter A.),
K. Kendler (K.),
B.P.C. Koeleman (Bobby),
C.A. Mathews (Carol A.),
Price, A. (Alkes),
J.M. Scharf,
P. Sklar (Pamela),
Williams, J. (Julie),
Wood, N.W. (Nicholas W.),
Cotsapas, C. (Chris),
Palotie, A. (Aarno),
J.W. Smoller,
P.F. Sullivan (Patrick),
Rosand, J. (Jonathan),
A. Corvin (Aiden)
and
B.M. Neale (Benjamin)
2018-06-22
Analysis of shared heritability in common disorders of the brain
Publication
Publication
Science , Volume 360 - Issue 6395
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Additional Metadata | |
---|---|
Persistent URL | doi.org/10.1126/science.aap8757, hdl.handle.net/1765/110715 |
Journal | Science |
Organisation | Department of Epidemiology |
Citation |
Anttila, V. (Verneri), Bulik-Sullivan, B., Finucane, H. K., Walters, R., Bras, J. (Jose), Duncan, L. (Laramie), … Neale, B. (2018). Analysis of shared heritability in common disorders of the brain. Science, 360(6395). doi:10.1126/science.aap8757 |