Purpose: To test and compare different registration approaches for performing whole-body diffusion-weighted (wbDWI) image station mosaicing, and its alignment to corresponding anatomical T1 whole-body image. Methods: Four different registration strategies aiming at mosaicing of diffusion-weighted image stations, and their alignment to the corresponding whole-body anatomical image, were proposed and evaluated. These included two-step approaches, where diffusion-weighted stations are first combined in a pairwise (Strategy 1) or groupwise (Strategy 2) manner and later non-rigidly aligned to the anatomical image; a direct pairwise mapping of DWI stations onto the anatomical image (Strategy 3); and simultaneous mosaicing of DWI and alignment to the anatomical image (Strategy 4). Additionally, different images driving the registration were investigated. Experiments were performed for 20 whole-body images of patients with bone metastases. Results: Strategies 1 and 2 showed significant improvement in mosaicing accuracy with respect to the non-registered images (P < 0.006). Strategy 2 based on ADC images increased the alignment accuracy between DWI stations and the T1 whole-body image (P = 0.0009). Conclusions: A two-step registration strategy, relying on groupwise mosaicing of the ADC stations and subsequent registration to T1, provided the best compromise between whole-body DWI image quality and multi-modal alignment. Magn Reson Med 79:1684–1695, 2018.

diffusion-weighted MRI, image registration, MR station mosaicing, multi-station acquisition, whole-body MRI
dx.doi.org/10.1002/mrm.26787, hdl.handle.net/1765/111126
Magnetic Resonance in Medicine
Erasmus MC: University Medical Center Rotterdam

Ceranka, J. (Jakub), Polfliet, M, Lecouvet, F.E, Michoux, N. (Nicolas), de Mey, J. (Johan), & Vandemeulebroucke, J. (2018). Registration strategies for multi-modal whole-body MRI mosaicing. Magnetic Resonance in Medicine, 79(3), 1684–1695. doi:10.1002/mrm.26787