Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Ping, Zhen; Chen, Si; Hermans, Sjoerd J. F.; Kenswil, Keane; Feyen, Jacqueline; van Dijk, Claire; Bindels, Eric; Mylona, Maria-Anthina; Adisty, Maria; Hoogenboezem, Remco; Sanders, Mathijs; Cremers, Eline; Lindenbergh-Kortleve, Dicky; Samsom, Janneke; van de Loosdrecht, Arjan; Raaijmakers, Marc

doi:10.1038/s41375-018-0267-x

Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

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Persistent URL	doi.org/10.1038/s41375-018-0267-x, hdl.handle.net/1765/111155
Journal	Leukemia
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Ping, Z., Chen, S., Hermans, S.J.F. (Sjoerd J. F.), Kenswil, K., Feyen, J. (Jacqueline), van Dijk, C. (Claire), … Raaijmakers, M. (2018). Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia. doi:10.1038/s41375-018-0267-x

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Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

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Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

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