2018
Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes
Publication
Publication
Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.
| Additional Metadata | |
|---|---|
| doi.org/10.1038/s41375-018-0267-x, hdl.handle.net/1765/111155 | |
| Leukemia | |
