Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of NF-κB attenuates HSPC numbers and function ex vivo.

doi.org/10.1038/s41375-018-0267-x, hdl.handle.net/1765/111155
Leukemia

Ping, Z, Chen, S, Hermans, S.J.F. (Sjoerd J. F.), Kenswil, K.J.G, Feyen, J. (Jacqueline), van Dijk, C. (Claire), … Raaijmakers, M.H.G.P. (2018). Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes. Leukemia. doi:10.1038/s41375-018-0267-x