Studies on the role of Gata3 during development

Almost all cells in the living organism have identical genetic information, but each cell type expresses a limited number of genes. This phenomenon is regulated by specific proteins: transcription factors. These factors have the ability to recognize target sequences located at specific regulatory fragments located in or surrounding the gene (promoter, enhancer or LCR) and activate or repress gene transcription. Like many genes, the expression of transcription factors can also be restricted to particular cell types. This thesis is focused on the transcription factor GATA3, which is expressed in tissue specific manner during development. This chapter will introduce this factor and describes its sites of expression with the main focus on skin.