The past decade has witnessed a substantial change in methods and approaches of genetic studies, including those of the vitamin D endocrine system. From using candidate gene studies in small-study populations lacking replication, we went to applying genome-wide association studies in large-scale collaborative consortia with built-in replication studies. This has led to robust genetic discoveries and applying these in so-called Mendelian randomization studies to distinguish cause from effect in epidemiological relationships. Background, context, and results of such genetic studies are here discussed. Their outcomes point to a role of the vitamin D endocrine system in our immune system and in our interactions with the various microbiome communities in and on our body.

Additional Metadata
Keywords Genetic, GWAS, Mendelian randomization, Microbiome, Polymorphism
Persistent URL,
Rights no subscription
Uitterlinden, A.G. (André G.). (2017). Genetics of the Vitamin D Endocrine System. In Vitamin D: Fourth Edition (pp. 151–165). doi:10.1016/B978-0-12-809963-6.00065-1