The past decade has witnessed a substantial change in methods and approaches of genetic studies, including those of the vitamin D endocrine system. From using candidate gene studies in small-study populations lacking replication, we went to applying genome-wide association studies in large-scale collaborative consortia with built-in replication studies. This has led to robust genetic discoveries and applying these in so-called Mendelian randomization studies to distinguish cause from effect in epidemiological relationships. Background, context, and results of such genetic studies are here discussed. Their outcomes point to a role of the vitamin D endocrine system in our immune system and in our interactions with the various microbiome communities in and on our body.

Genetic, GWAS, Mendelian randomization, Microbiome, Polymorphism
dx.doi.org/10.1016/B978-0-12-809963-6.00065-1, hdl.handle.net/1765/111365
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Erasmus MC: University Medical Center Rotterdam

Uitterlinden, A.G. (André G.). (2017). Genetics of the Vitamin D Endocrine System. In Vitamin D: Fourth Edition (pp. 151–165). doi:10.1016/B978-0-12-809963-6.00065-1