Context: Although the skeleton is a well-known thyroid hormone target organ, very little data are available on the association of thyroid function with bone outcomes during childhood.Objective: To study the association of thyroid function with bone mass during childhood.Design, Setting, and Participants: Population-based prospective cohort including 4204 children with TSH and free T4 (FT4) measured at the age of 6 years.Main Outcome Measures: Bone density was assessed by a total body dual-energy X-ray absorptiometry scan at the median age of 6 years (95% range, 5.6 to 7.9) and at the age of 10 years (95% range, 9.0 to 10.9) in 4204 and 3404 participants, respectively.Results: There was an inverse association of TSH with bone mineral density (BMD) at the age of 6 (β -0.028 ± 0.011, P = 0.009) and with follow-up measurements at the age of 10 (β -0.027 ± 0.011, P = 0.014), but not with bone mineral content (BMC) at the age of 6 (β -0.028 ± 0.015, P = 0.06) or for follow-up measurements of BMC at the age of 10 (β -0.011 ± 0.015, P = 0.47). There was an inverse association of FT4 with BMD (β -0.016 ± 0.006, P = 0.014) and BMC (β -0.023 ± 0.009, P = 0.009) cross-sectionally, and also at the age of 10 years (BMD: β -0.018 ± 0.007, P = 0.007; BMC: β -0.021 ± 0.009, P = 0.020).Conclusion: A higher FT4 concentration is associated with lower bone mass at the age of 6 and at the age of 10 years. These data provide insights into the effects of thyroid function on bone physiology during childhood.

Additional Metadata
Persistent URL dx.doi.org/10.1210/jc.2018-00294, hdl.handle.net/1765/111429
Journal Journal of Clinical Endocrinology and Metabolism
Citation
Veldscholte, K. (Karlien), Barjaktarović, M, Trajanoska, K, Jaddoe, V.W.V, Visser, T.J, de Rijke, Y.B, … Korevaar, T.I.M. (2018). The Association of Thyroid Function With Bone Density During Childhood. Journal of Clinical Endocrinology and Metabolism, 103(11), 4125–4134. doi:10.1210/jc.2018-00294