Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: A pooled analysis of seven European birth cohort studies
International Journal of Epidemiology , Volume 47 - Issue 4 p. 1082- 1097
Background: Attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide for reasons largely unknown and environmental chemicals with neurotoxic properties, such as persistent organic pollutants (POPs), have been proposed to play a role. We investigated the association between prenatal and postnatal exposure to polychlorinated biphenyl-153 (PCB-153), p-ṕ-dichlorodiphenyldichloroethylene (p-ṕ-DDE) and hexachlorobenzene (HCB) and ADHD in childhood. Methods: We pooled seven European birth cohort studies encompassing 4437 mother- child pairs from the general population with concentrations of PCB-153, p-ṕ-DDE and HCB measured in cord blood, maternal blood or milk. We then calculated prenatal (birth) and postnatal (3, 6, 12 and 24months) POP concentrations using a pharmacokinetic model. The operational definition of ADHD varied across cohorts and ranged from doctor diagnosis obtained from patient registries to maternal or teachers reports. We used multilevel (mixed) logistic regression models to estimate the associations between exposure to POPs at birth, 3, 6, 12 and 24 months and ADHD. Results: The global prevalence of ADHD in our study was 6%. The mean age at assessment of ADHD was 5.8 years (range: 3.8-9.5 years). We found no association between exposure to PCB-153, p-ṕ-DDE and HCB at any age point between birth and 24months and ADHD, in the pooled analyses (pooled odds ratios ranging from 1.00 to 1.01). A number of sensitivity analyses gave basically the same results. Conclusions: In the largest study to date of 4437 children in seven European birth cohorts, we did not observe any association between either pre- or postnatal exposure (up to 24 months) to PCB-153, p-ṕ-DDE and HCB and the risk of ADHD before the age of 10 years.
|Attention-deficit disorder with hyperactivity, DDT, Hexachlorobenzene, Polychlorinated biphenyls|
|International Journal of Epidemiology|
|This work was funded by the European Commission 7th Framework Programme; grant id fp7/282957 - Developmental neurotoxicity assessment of mixtures in children (DENAMIC), This work was funded by the European Commission 7th Framework Programme; grant id fp7/212502 - Contaminant mixtures and human reproductive health - novel strategies for health impact and risk assessment of endocrine disrupters (CONTAMED)|
Forns, J, Stigum, H, Høyer, B.B. (Birgit Bjerre), Sioen, I. (Isabelle), Sovcikova, E. (Eva), Nowack, N. (Nikola), … Eggesbø, M. (2018). Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: A pooled analysis of seven European birth cohort studies. International Journal of Epidemiology, 47(4), 1082–1097. doi:10.1093/ije/dyy052