The excellent mechanical properties, wide body distribution, and important physiological functions of the biocorrodible metal iron  render it a promising candidate as a building block for a biocorrodible metal scaffold. To this end, pure iron scaffolds appear safe and demonstrate outstanding biocompatibility in rabbit and porcine abdominal aortas and porcine coronary arteries [2-4], and Fe(II) and Fe(III) inhibit vascular smooth muscle cell proliferation in vitro by reducing proliferation-related gene expression [5-7]. However, studies on a biodegradable iron scaffold have been scarce, and an iron scaffold is currently not commercially available.
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Gao, R, Zhang, D, Qiu, H, Wu, C, Xia, Y, & Zhang, G. (2017). Iron. In Bioresorbable Scaffolds: From Basic Concept to Clinical Applications (pp. 117–121). Retrieved from http://hdl.handle.net/1765/111572