CONCLUSION: Considering the large number of patients treated until now and the efficacy and good safety profile of this treatment, the authors plead that intralesional laser treatment may be considered as a treatment option before surgery.CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.BACKGROUND: For complications caused by filler treatments, in general, two treatment regimens are advised: systemic drugs and surgical removal of the material. Another possible treatment option would be removal of the material by intralesional laser treatment.METHODS: Two hundred forty-two patients with complications caused by fillers were treated with intralesional laser treatment.RESULTS: In the majority of patients, an improvement was achieved (92 percent), in 9 percent the complication was resolved, and in 3 percent it was not improved (unknown in the rest).