Magnesium : Epidemiological aspects of a forgotten electrolyte

Serum magnesium plays a role in a wide range of cellular functions and it has been linked to many disease. Within the Rotterdam Study, a population-based cohort study, we measured serum magnesium levels routinely in all participants, irrespective of their health status or drug use. We found that proton pump inhibitor use and thiazide diuretics use were associated with lower serum magnesium levels and were associated with hypomagnesemia. We also found that lower serum magnesium levels were associated with an increased risk of diabetes mellitus, dementia, and death due to coronary heart disease and sudden cardiac death.

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