Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls. SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. SOX2 antibodies are specific (>90%) markers for SCLC, but are rarely found in patients with other tumours, whether neurological symptoms are present or not.

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Journal of Neuroimmunology
Department of Neurology

Maddison, P. (Paul), Titulaer, M., Verschuuren, J., Gozzard, P. (Paul), Lang, B. (Bethan), Irani, S.R. (Sarosh R.), … Chapman, C.J. (Caroline J.). (2019). The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders. Journal of Neuroimmunology, 326, 14–18. doi:10.1016/j.jneuroim.2018.11.003