LRP10 in α-synucleinopathies – Authors' reply

We thank Kia and colleagues, Guerreiro and colleagues, Pihlstrøm and colleagues, Tesson and colleagues, and Shi and colleagues for their interest in our work.
Kia and colleagues, Guerreiro and colleagues, and Pihlstrøm and colleagues seek replication of our findings by mining existing wholeexome sequencing data from patients with Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy and controls, mostly of white ancestry. They conclude that evidence for association of rare LRP10 variants with disease was not found. We appreciate their efforts to replicate our results, but we have a number of concerns regarding these analyses.