Purpose: In critical illness, the relation between the macrocirculation, microcirculation and organ dysfunction, such as acute kidney injury (AKI), is complex. This study aimed at identifying predictors for AKI in patients with cardiogenic shock. Materials and methods: Thirty-nine adult cardiogenic shock patients, with an admission creatinine <200 μmol l−1, and whose microcirculation was measured within 48 h were enrolled. Patient data were analyzed if AKI stage ≥1 developed according to the Kidney Disease/Improving Outcomes classification within 48 h after admission. Variables with a p <.05 in the univariate analysis were considered for analysis with logistic regression. Results: Twenty-four patients (61.5%) developed AKI within 48 h. The group that developed AKI had higher central venous pressures (CVP), lower diastolic arterial blood pressures and mean perfusion pressures, higher maximum ventilator pressures as well as positive end expiratory pressures and were treated with higher dosages of dobutamine. There was no difference of the microcirculation. In the multivariate logistic regression analysis, CVP was the only independent predictor for AKI (OR 1.241; 95% CI 1.030–1.495; p =.023). Conclusions: In this population of patients with cardiogenic shock, CVP was associated with the development of AKI.

Additional Metadata
Keywords Central Venous pressure, Hemodynamics, Mechanical ventilation, Microcirculation, Organ failure, Risk factors
Persistent URL dx.doi.org/10.1016/j.jcrc.2018.11.004, hdl.handle.net/1765/112282
Journal Journal of Critical Care: improving patient care by integrating critical care systems knowledge into practice behavior
Citation
Van Den Akker, J.P.C, Bakker, J. (Jan), Groeneveld, A.B.J. (A. B.J.), & den Uil, C.A. (2019). Risk indicators for acute kidney injury in cardiogenic shock. Journal of Critical Care: improving patient care by integrating critical care systems knowledge into practice behavior, 50, 11–16. doi:10.1016/j.jcrc.2018.11.004