The emergence of antimicrobial resistance (AMR) and its linkage to misuse of antimicrobial agents, highlights the need to better understand the key features of their action and use. These principles apply equally to human, animal, and agricultural settings because it is clear that antimicrobial use has increased dramatically in all sectors over the past decades (WHO, 2012; WHO, 2015; Van Boeckel et al., 2014; Van Boeckel et al., 2015; O’Neill, 2016). This chapter will focus primarily on human antimicrobial use, and nonhuman use is discussed elsewhere (see Chapter 2, Use of Critically Important Antimicrobials in Food Production).

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Grayson, M.L. (M. Lindsay), Cosgrove, S.E. (Sara E.), Crowe, S, McCarthy, J.S. (James S.), Hope, W. (William), Mills, J. (John), … Paterson, D.L. (David L.). (2017). Principles of antimicrobial use. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 3–8). doi:10.1201/9781315152110