Tigecycline is the first glycylcycline that became available for clinical use and is a member of the tetracycline family. The chemical name for tigecycline is (4S,4aS,5aR,12aS)-9-[2- (tert-butylamino)acetamido]-4,7-bis(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tet-rahydroxy- 1,11-dioxo-2-naphthacenecarboxamide. The empirical formula is C29H39N5O8 and the molecular weight is 585.65. Tigecycline is a semisynthetic derivative of minocycline; it has a glycylamido moiety attached to the C-9 position of minocycline (Sum et al., 1994; Hunter and Castaner, 2001). The molecular structure is shown in Figure 70.1. Tigecycline is produced by Wyeth under the trade name Tygacil.
|Organisation||Department of Medical Microbiology and Infectious Diseases|
Nabuurs-Franssen, M.H. (Marrigje H.), Lestrade, B.P.A. (Bram P. A.), & Mouton, J.W. (Johan W.). (2017). Tigecycline. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 1249–1266). doi:10.1201/9781315152110