Spectinomycin is an aminocyclitol compound that has some structural similarities to streptomycin, but it differs by not being an aminoglycoside. Spectinomycin was isolated in 1960 from Streptomyces spectabilis in the Upjohn Research Laboratories (Mason et al., 1961). It was originally known as actinospectacin and was manufactured as the sulfate salt. Later, it was manufactured as the more soluble dihydrochloride salt. The empiric formula is C14H36Cl2N2O12 and the molecular weight is 495.3. The chemical structure of spectinomycin is shown in Figure 87.1. The clinical use of this drug has been restricted to the treatment of gonorrhea.
|Organisation||Department of Medical Microbiology and Infectious Diseases|
Mouton, J.W. (Johan W.). (2017). Spectinomycin. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 1542–1546). doi:10.1201/9781315152110